Conformationally locked 7-aryl tetrahydroisoquinolines as dual acetylcholinesterase inhibitors
and antioxidants: role of intramolecular hydrogen bonding and aryl electronics
Ríos, V.; Linares-Pipón, C.; Maulén, C.; Castro-Álvarez, A.; Bradshaw, B.; Romero-Parra, J.; Cuellar, M.; Martínez-Cifuentes, M.* and Parra, C.*
Front. Pharmacol. 2026, 17, 1797738. https://doi.org/10.3389/fphar.2026.1797738
Pharmacological and molecular characterization of a chalcone analogue derived from a
Senecio nutans metabolite: Modulation of CaV1.2 and KCa1.1 channels in hypertensive rats
Asunción-Alvarez, D.; Palacios, J.; Cifuentes, F.; Ruiz, K. B.; Paredes, A.; Brito, I.; Delgado, G. E.; Nwokocha, C. R. and Parra, C.
British Journal of Pharmacology 2026, 183(16), 4899–4918. https://doi.org/10.1111/bph.70497
Structure-guided hydrophobic modulation at the 3-position of Senecio nutans
derived chalcones drives divergent vascular mechanisms
Palacios, J.; Yu González, C. L.; Aravena, D.; Romero-Parra, J.; Martínez-Cifuentes, M.*; and Parra, C.*
Front. Pharmacol. 2026, 17, 1772443. https://doi.org/10.3389/fphar.2026.1772443
Metabolites Isolated from Senecio nutans Sch. Bip and Their Synthesized Oximes Inhibit Angiotensin I-Converting Enzyme Activity in Vascular Smooth Muscle
Palacios, J.; Villarroel, C.; Asunción-Alvarez, D.; Cifuentes, F.; Paredes, A.; Nwokocha, C.R.; Castro-Álvarez, A. and Parra, C.*
Int. J. Mol. Sci. 2025, 26, 3786. https://doi.org/10.3390/ijms26083786
The Madangamines: Synthetic Strategies Toward Architecturally Complex Alkaloids
Ríos, V.; Maulen, C.; Parra, C.* and Bradshaw, B.*
Mar. Drugs 2025, 23, 301 https://doi.org/10.3390/md23080301
Identification of Antioxidant Methyl Derivatives of Ortho-Carbonyl Hydroquinones That Reduce Caco-2 Cell Energetic Metabolism and Alpha-Glucosidase Activity
Monroy-Cárdenas, M.; Almarza, C.; Valenzuela-Hormazábal, P.; Ramírez, D.; Urra, F.A.; Martínez-Cifuentes, M.*; Araya-Maturana, R.*
Int. J. Mol. Sci. 2024, 25, 8334. https://doi.org/10.3390/ijms25158334
A new oxime synthesized from Senecio nutans SCh. Bip (chachacoma) reduces calcium influx in the vascular contractile response in rat aorta
Palacios, J.; Asunción-Alvarez, D.; Aravena, D.; Chiong, M.; Catalán, M. A.; Parra, C.; Cifuentes and F.; Paredes, A.
RSC Adv. 2024, 14 (14): 9933–9942. https://doi.org/10.1039/d4ra01058b
Design of β-Keto Esters with Antibacterial Activity: Synthesis, In Vitro Evaluation,
and Theoretical Assessment of Their Reactivity and Quorum-Sensing Inhibition Capacity
Martínez-Cifuentes, M.; Soto-Tapia, E.; Linares-Pipón, C.; Bradshaw, B.; Valenzuela-Hormazabal, P.; Ramírez, D.; Muñoz-Torres, P.; Parra, C.*
Pharmaceuticals 2023, 16, 1339. https://doi.org/10.3390/ph16101339
An In Vitro and In Silico Study of Antioxidant Properties of Curcuminoid N-alkylpyridinium Salts: Initial Assessment of Their Antitumoral Properties
Forero-Doria, O.; Guzmán, L.; Jiménez-Aspee, F.; Echeverría, J.; Wehinger, S.; Valenzuela, C.; Araya-Maturana, R.*; Martínez-Cifuentes, M.*
Antioxidants 2022, 11, 1104. https://doi.org/10.3390/antiox11061104
Cytotoxic Effects on Breast Cancer Cell Lines of Chalcones Derived from
a Natural Precursor and Their Molecular Docking Analysis
Bustos, L.; Echiburú-Chau, C.; Castro-Alvarez, A.; Bradshaw, B.; Simirgiotis, M.J.; Mellado, M.; Parra, C.*; Cuellar, M.*
Molecules 2022, 27, 4387. https://doi.org/10.3390/molecules27144387